Coated pits can concentrate large extracellular molecules that have different receptors responsible for the receptor-mediated endocytosis of ligands, e.g. low density lipoprotein, transferrin, growth factors, antibodies and many others.

A coated pit is a structure on the plasma membrane that plays a role in receptor-mediated endocytosis by facilitating the internalization of macromolecules such as ligands, hormones, and growth factors into the cell.

May 29, 2023 · Specialised regions of the cell membrane composed of pits coated with a bristle covering made of the protein clathrin. These pits are the entry route for macromolecules bound by cell surface receptors.

Jan 12, 2025 · Coated pits are specialized regions of the cell membrane that are involved in the internalization of extracellular material. They are composed of a protein coat, which underlies the invagination of the membrane to form a pit-like structure.

Aug 3, 2012 · The “canonical” coated pit is an invaginating structure, in which assembly of a curved clathrin lattice, linked by adaptors and other proteins to deformation of the underlying membrane, gives rise, by constriction and (dynamin-catalyzed) scission, to a coated vesicle (Kirchhausen, 2009; Traub, 2009). Because it takes place at the cell ...

Recently, the study of endocytosis has extended into the living cell. The tracking of individual clathrin-coated pits and vesicles (CCPs and CCVs) has provided new insight into understanding the dynamic nature of CCPs.

In this review we examine the canonical model of CME, highlight discrepancies with published experimental data and suggest future avenues of exploration while paying particular attention to the relationship between clathrin coated pits, plaques, sites of adhesion and the formation of endocytic 'hotspots'.

Sep 8, 2009 · Coated pits are small, rapidly forming structures that deform the underlying membrane by progressive recruitment of clathrin, adaptors, and other regulatory proteins. They ultimately close off and bud inward to form coated vesicles.

Feb 21, 2024 · Clathrin-coated pits are invaginations of the cell membrane characterized by a lattice-like coat composed of the protein clathrin. Clathrin molecules assemble into a hexagonal lattice, providing structural support and facilitating the budding of vesicles from the membrane during endocytosis.

Apr 29, 1999 · Diffusible transmembrane receptors or membrane-docking sites are thought to recruit AP-2 and clathrin to form a coated pit. But the new data indicate that coated-pit formation is coupled to...