Lck Antibody detects endogenous levels of total Lck protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the …

Feb 17, 2022 · ORP4L deletion blocks Tax-induced T-cell leukemia, whereas engineering ORP4L expression in T cells results in T-cell leukemia in mice. Loss of miR-31 induced by Tax …

Oct 30, 2024 · Here we show that the enzyme N-acetyltransferase 10 (NAT10) regulates T cell activation and proliferation upon antigen stimulation. T cell-specific NAT10 deficiency in mice …

These kinases, including LCK, LAT, ITK, PLC- γ 1, P65, ERKI/II, and JAK/STATs, are required for peripheral CD8 T cell persistent function during alloimmunity. Overall, our molecular and …

Here, we found that Lck-cre-mediated T cell-specific loss of Paxbp1 (abbreviated as Paxbp1 cKO) resulted in thymic atrophy and significant reductions in the numbers of DP cells, CD4 + SP, …

Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth. …

Jan 1, 2015 · Using chimera mice consisting of both WT and Apc-deficient T cells, we found that loss of naïve T cells is due to T-cell intrinsic dysregulation of Wnt signaling. Since Apc deletion …

Conditional knockout (cKO) mice are extremely valuable for biomedical research because they enable detailed analyses of gene functions in a tissue- or temporally-specific fashion.

Feb 2, 2022 · Tax transgenic mice have been reported to develop T-cell leukemia. 26-28 LCK/R26 Tax mice developed T-cell leukemia at the age of ∼18 months and died within 25 …