Cebpd Mdsc - Search

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The CCAAT/Enhancer-Binding Protein Family: Its Roles in MDSC …
To better understand the MDSC-associated transcriptional network and identify new therapy targets, we herein review recent findings about the C/EBP family regarding their participation …
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
C/EBP-δ positively regulates MDSC expansion and endothelial …
In this study, we identify C/EBP-δ as a common mediator that regulates the expansion of MDSCs in tumor conditions as well as VEGFR2 expression in vascular endothelial cells, two important …
Nature
https://www.nature.com › articles
Basic biology and roles of CEBPD in cardiovascular disease
4 days ago · Aberrant CEBPD expression and activity are associated with multiple organ diseases, including cardiovascular diseases. ... Lin PC. C/EBP-delta positively regulates …
Studies of Cebpd Mdsc
PubMed
Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression
Sepsis-induced myeloid-derived suppressor cells (MDSCs) contribute to immunosuppression associated with sepsis. We reported that the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions, which induce transcription factor NFI-A to support the generation and expan...
Author: Jun Dai
Published: 2017/11
Keywords: C/EBPβ; I…
ScienceDirect
Review Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage
Monocyte/macrophages play an important role in orchestrating the immune response. The present review refers to C/EBPβ, which is a key transcription factor regulating monocytic gene expression. Following a general introduction to C/EBPβ, this article focuses on activators and regulators of the C/EBPβ...
Published: 2012/06/01
Cited By: 0
Keywords: Monocytic …
PubMed
CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs
CCAAT/enhancer-binding protein delta (C/EBPδ) is a member of the C/EBP family of transcription factors. According to the current paradigm, C/EBPδ potentiates cytokine production and modulates macrophage function thereby enhancing the inflammatory response. Remarkably, however, C/EBPδ deficiency does...
Author: C Arnold Spek
Published: 2021/08/28
Keywords: CCAAT/en…
PubMed
https://pubmed.ncbi.nlm.nih.gov
Expression of C/EBPβ in myeloid progenitors during sepsis …
We reported that the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions, which induce transcription factor NFI-A to support the generation and …
- Author: Jun Dai, Ajinkya Kumbhare, Dima Youssef, Zhi Q. Yao, Charles E. McCall, Mohamed El Gazzar
- Publish Year: 2017
ScienceDirect
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The dual role of C/EBPδ in cancer - ScienceDirect
May 1, 2023 · Moreover, myeloid derived suppressor cells (MDSC), a cell type whose levels are elevated in cancer patients and that limits immune cell function and immune surveillance while …
Cell Press
https://www.cell.com › cell-reports-medicine › fulltext
Single-cell profiling reveals a conserved role for hypoxia-inducible ...
Oct 18, 2024 · Transcriptional profiling revealed leukocyte diversity typified by a prominent G-MDSC signature and altered immunometabolic profiles, including hypoxia-inducible factor 1a …
People also ask
Does removing C/EBP reduce the production of MDSCs?
Deletion of C/EBPδ in mice significantly reduced the production of MDSCs upon the subcutaneous implantation of 3LL lung carcinoma cells as compared to that in tumor-bearing, C/EBPδ-proficient mice.
The dual role of C/EBPδ in cancer - ScienceDirect
sciencedirect.com
Where is CEBPD located?
CEBPD is an intronless gene with only one known isoform and is located at genomic location 8q11.21 (Wang et al., 2015).
The dual role of C/EBPδ in cancer - ScienceDirect
sciencedirect.com
Why are myeloid derived Suppressor Cells (MDSC) elevated in cancer patients?
Moreover, myeloid derived suppressor cells (MDSC), a cell type whose levels are elevated in cancer patients and that limits immune cell function and immune surveillance while promoting tumor angiogenesis and growth, express high levels of C/EBPδ.
The dual role of C/EBPδ in cancer - ScienceDirect
sciencedirect.com
Does CEBPD amplification co-occur with Myc?
In urothelial carcinoma, CEBPD amplification co-occurs with MYC amplification in 29.6% of all cases. This co-amplification has been attributed to a positive feedback loop in which CEBPD prevents FBXW7-mediated degradation of MYC and MYC promotes CEBPD amplification by facilitating chromosomal instability (Chan et al., 2021).
The dual role of C/EBPδ in cancer - ScienceDirect
sciencedirect.com
What is a MDSC cell?
MDSCs represent a heterogeneous population of myeloid cells composed of macrophages, granulocytes and dendritic cells that are at early stages of development. Under physiological conditions they represent up to 20–30% of BM cells and ~4% of nucleated cells in the spleen .
Signaling pathways involved in MDSC regulation - PMC
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Which signaling pathways are involved in the regulation of MDSC function?
There is immense interest in elucidating the role of signaling pathways that are involved in the regulation of MDSC function. Most signaling pathways function by activating transcription factors and genes that are involved in cell proliferation, survival, and differentiation.
Signaling pathways involved in MDSC regulation - PMC
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Signaling pathways involved in MDSC regulation - PMC
BALB/c Ptger2 (EP2) knockout mice inoculated with 4T1 mammary carcinoma cells had delayed tumor growth and reduced numbers of MDSC, suggesting that PGE2 partially mediates MDSC induction through the EP2 receptor.
ResearchGate
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(PDF) C/EBP-δ positively regulates MDSC expansion and …
Mar 21, 2017 · Vascular endothelial cells and Gr-1+CD11b+ myeloid derived suppressor cells (MDSCs) are two important components that constitute the tumor microenvironment. Targeting …
Oncotarget
https://www.oncotarget.com › article › text
C/EBP-δ positively regulates MDSC expansion and
Mar 21, 2017 · In this study, we identify C/EBP-δ as a common mediator that regulates the expansion of MDSCs in tumor conditions as well as VEGFR2 expression in vascular endothelial cells, two important populations of cells that …
Cell Press
https://www.cell.com › cell-metabolism › pdf
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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells …
We have found that tumor glycolysis regulates the expression of the secondary isoform of CCAAT/enhancer-bind-ing protein beta (CEBPB), liver-enriched activator protein (LAP), via …
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