The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest.

Jun 3, 2020 · CDC25C is a novel partner for down-regulation of P53 transcription. The CDC25C gene contains a P53 binding site and P53 inhibition by the CDC25C promoter induces G2/M arrest after DNA damage.

Jan 30, 2015 · Cdc25C exhibits basal phosphatase activity during interphase and then becomes activated at the G 2 /M transition after hyperphosphorylation on multiple sites and dissociation from 14-3-3....

Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. [1] . As with other cell cycle proteins or genes such as Cdc2 and Cdc4, the "cdc" in its name refers to " c ell d ivision c ycle". [2] .

Jun 3, 2020 · This review summarizes the role of CDC25C phosphatase in regulating cell cycle. Based on the role of CDC25 family proteins in the development of tumors, it will become a hot target for a new generation of cancer treatments.

Dec 24, 2024 · CDC25C (Cell Division Cycle 25C) is a Protein Coding gene. Diseases associated with CDC25C include Myeloproliferative Neoplasm and Hematologic Cancer. Among its related pathways are Gene expression (Transcription) and Defective Intrinsic Pathway for Apoptosis.

Feb 9, 2025 · CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma. Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.

CDC25, dual specificity phosphatase (DSP), is an important checkpoint component, and dysregulation of CDC25 can contribute to genomic instability. Genomic instability occurs when cell continues to divide and the DNA lesion is passed to daughter cells due to …

CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma. Zhou C, et al. Bioengineered, 2022 May. PMID 35615982, Free PMC Article. Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.

Cell division cycle 25 (CDC25) phosphatases are key regulators of the eukaryotic cell cycle. They are required to control cyclin-dependent kinase (CDK) dephosphorylation and activation in a...