M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

Cdc25A activates cyclin D-CDK4 complex and cyclin E-CDK2 complex, which phosphorylate Rb and dissociate Rb from complex with E2F1, releasing inhibition on E2F1, whose activity is essential for G 1 /S transition.

Dec 24, 2024 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups.

Overexpression of Cdc25A promotes tumorigenesis, and is frequently observed in various types of cancer. Here we briefly summarize current understanding of the role of Cdc25A in cell proliferation and apoptosis, as well as the impact of overexpression of Cdc25A on tumorigenesis.

Most other model organisms examined have three Cdc25s, designated Cdc25A, Cdc25B, and Cdc25C. An exception is the nematode Caenorhabditis elegans , which has four distinct Cdc25 genes (Cdc-25.1 to Cdc-25.4).

Feb 8, 2025 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups.

Jan 4, 2025 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups.

The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression that acts on the phosphorylation status of Cyclin-Cyclin-dependent kinase complexes, with an emergent role in the DNA damage response and cell survival control.

Dec 10, 2024 · CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups.

Feb 24, 2010 · CDC25A mainly activates the CDK2 (116953)-cyclin E (123837) and CDK2-cyclin A (123835) complexes during the G1-S transition, but also has a role during the G2-M transition by activating CDK1 (116940)-cyclin B (123836) complexes, which are thought to initiate chromosome condensation (summary by Boutros et al., 2007).