/calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca 2+ / calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory . [ 1 ]

Sep 2, 2022 · Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory.

Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases widely expressed in many tissues that is capable of mediating diverse functional responses depending on its cellular and molecular microenvironment.

Mar 21, 2024 · Additionally, CaMKII is a multifunctional protein kinase that can phosphorylate a large variety of substrate proteins at Ser/Thr residues and thereby contribute to a variety of Ca 2+ -induced functions. This review aims to help you, the reader, to study the role of CaMKII in your favorite cell type and/or your favorite cellular function.

Calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is activated by intracellular increases in calcium ion levels and triggers molecular processes necessary for synaptic plast …

Mar 1, 2002 · Calcium/calmodulin-dependent protein kinase II (CaMKII) is necessary for LTP induction, is persistently activated by stimuli that elicit LTP, and can, by itself, enhance the efficacy of...

Jun 25, 2019 · Calcium (Ca 2+)/calmodulin-dependent kinase II (CaMKII), a serine/threonine kinase, is critical for various forms of synaptic plasticity that underlie learning and memory. CaMKII is...

Jan 20, 2023 · CaMKII (the multifunctional Ca 2+ and calmodulin-dependent protein kinase II) is a highly validated signal for promoting a variety of common diseases, particularly in the cardiovascular system. Despite substantial amounts of convincing preclinical data, CaMKII inhibitors have yet to emerge …

Dec 31, 2024 · Here, we show that Ca 2+ /calmodulin-dependent protein kinase II β (CaMKIIβ) integrates ER Ca 2+ transients to trigger liquid-liquid phase separation (LLPS) of the autophagosome-initiating FIP200 complex.

Nov 11, 2014 · Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is known to play key roles in synaptic plasticity. It has a dodecameric structure composed of four different isoforms α–δ.