Feb 9, 2022 · Using p53 -null orthotopic and ectopic models of murine HCC, we find that combining CXCR4-targeted p53 mRNA nanoparticles with anti-PD-1 therapy effectively induces global reprogramming of...

The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone marrow. However, CXCR4 also directly controls cell proliferation of ...

May 17, 2007 · Mutation of the tumor suppressor gene p53 in breast cancer is associated with metastasis and aggressive clinical phenotype. In this report, we demonstrate that wild type but not the dominant-negative mutant (V143A) or cancer-specific mutants (R175H or R280K) of p53 repress CXCR4 expression.

Nov 27, 2006 · Mutation of the tumor suppressor gene p53 in breast cancer is associated with metastasis and aggressive clinical phenotype. In this report, we demonstrate that wild type but not the...

We found that gp120 stimulates p53 activity and induces expression of the p53 pro-apoptotic target Apaf-1 in cultured neurons. Inhibition of CXCR4 by AMD3100 abrogates the effect of gp120 on both p53 and Apaf-1. Moreover, gp120 neurotoxicity is …

HGF treatment induces CXCR4 receptor phosphorylation and can contribute to reduced CXCR4 endocytosis, thereby facilitating chemotactic migration of breast tumor cells . Wild-type p53 has been shown to repress CXCR4 expression, while the cancer-specific isoform of p53, Δ133p53 failed to repress CXCR4 promoter activity . This suggests an ...

Feb 9, 2022 · As p53 loss of function may play a role in immunosuppression, we herein examine the effects of restoring p53 expression on the immune TME and ICB efficacy. We develop and optimize a CXCR4-targeted mRNA nanoparticle platform to …

May 8, 2021 · Further, we detect that CXCR4 directs the differential recruitment of transcription factors p53 and YY1 to the promoter of DR5 in course of its transcriptional repression. Remarkably,...

Jan 7, 2025 · This study aimed to evaluate the expression patterns of five critical biomarkers: β-catenin, E-cadherin, podoplanin (PDPN), CXCR4, and p53 in OSCC tissues and to investigate their correlations with clinicopathologic features and patient outcomes.

Jan 7, 2025 · This study aims to evaluate the expression patterns of five key biomarkers β-catenin, E-cadherin, PDPN, CXCR4, and p53 in OSCC samples, using a tissue microarray (TMA) analysis and correlate their expression with clinical parameters and patient outcomes.