Blocking the CXCL1-CXCR2 axis enhances the effects of ... - Nature
Apr 10, 2023 · It has been shown that blocking CXCL1-CXCR2 inhibits tumour progression and reduces macrophage recruitment in the TME. The combination regimen has been shown to synergistically reduce the...
CXCR2 inhibition enables NASH-HCC immunotherapy - PubMed
Results: Neutrophils expressing CXCR2, a receptor crucial to neutrophil recruitment in acute-injury, are highly represented in human NASH-HCC. In models of NASH-HCC lacking response to ICI, the combination of a CXCR2 antagonist with anti-PD1 suppressed tumour burden and extended survival.
CXCR2 inhibition in NASH-HCC - Nature
May 24, 2022 · The authors will examine CXCR2 inhibition combined with the ICI durvalumab in a clinical trial (CUBIC) in unresectable advanced HCC, hoping to usher in a new therapeutic era in liver cancer ...
CXCR2 inhibition enables NASH-HCC immunotherapy - PMC
Neutrophils expressing CXCR2, a receptor crucial to neutrophil recruitment in acute-injury, are highly represented in human NASH-HCC. In models of NASH-HCC lacking response to ICI, the combination of a CXCR2 antagonist with anti-PD1 suppressed tumour burden and …
Targeted blocking of CCR2 and CXCR2 improves the efficacy of ...
Expression of CCL2/CCR2 and CXCLs/CXCR2 was analyzed in the primary rat HCC model and one HCC cohort. The relationship between expression levels, neutrophil and macrophage infiltration, hepatocarcinogenesis progression in the rat …
Targeted blocking of CCR2 and CXCR2 improves the efficacy of
Nov 19, 2022 · The CCL2/CCR2 and CXCLs/CXCR2 axes are required for recruitment of macrophages and neutrophils, respectively, in HCC. We investigated the feasibility of CCL2/CCR2 and CXCLs/CXCR2 as therapeutic targets in combination with TACE for …
Overcoming immunotherapy resistance in hepatocellular …
Feb 6, 2025 · Our data demonstrated that reconstructing TME through co-blockade of PD-L1 and CXCR2 indeed alters HCC progression. Targeting CXCR2 selectively relieved the immunosuppression mediated by MDSCs, thus creating a favorable immune context to improve tumor response to ICB.
CXCR2–CXCL1 axis is correlated with neutrophil infiltration and ...
Our data showed that the CXCR2 + cell density was an independent prognostic factor for predicting OS for HCC patients. The CXCR2–CXCL1 axis can regulate neutrophil infiltration into HCC tumor tissues and might represent a useful target for anti-HCC therapies.
C-X-C chemokine receptor 2 (Cxcr2) promotes hepatocellular
Feb 15, 2021 · Knockdown of Cxcr2 decreases PD-L1 levels and consequently promotes the shift of macrophages to the M1 phenotype, which is mediated by downregulating c-Myc. In summary, Cxcr2 is a potential target for suppressing immune escape in HCC.
CXCR2 inhibition enables NASH-HCC immunotherapy - Gut
Results Neutrophils expressing CXCR2, a receptor crucial to neutrophil recruitment in acute-injury, are highly represented in human NASH-HCC. In models of NASH-HCC lacking response to ICI, the combination of a CXCR2 antagonist with anti-PD1 suppressed tumour burden and extended survival.