Apr 1, 2020 · In mice, stimulation by a nonpeptidyl FPR agonist results in the downregulation of CXCR2 expression on neutrophils and failure to respond to C5a, LTB 4, or CXCL1 in calcium …

Oct 1, 2002 · To reveal functional consequences of CXCR1 and CXCR2 reduction caused by phagocytosis, we explored the effect of corresponding ligands, IL-8 and NAP-2, on intracellular …

May 24, 2019 · These data demonstrated that C5aR2 specifically transports C5a into the blood vessel lumen to induce neutrophil arrest, whereas ACKR1 specifically transports CXCR2 …

Regulating neutrophil CXCR2 and its ligand expression are potential therapeutic targets for controlling neutrophil recruitment and function in inflammatory disorders. CXCR2 is known to …

May 10, 2019 · Transported C5a was required to initiate C5aR1-mediated neutrophil arrest, whereas transported chemokines were required to initiate CXCR2-dependent neutrophil …

Using intravital multiphoton joint imaging of IC-induced arthritis in live mice, we found that the complement C5a receptor (C5aR) was the key initiator of neutrophil adhesion on joint …

In this review, we provide a comprehensive analysis of the role of the CXCL8-CXCR1/2 axis and select genes co-expressed in this pathway in disease progression. We also discuss the latest …

The peptide chemoattractants fMLP and C5a cross-desensitized CXCR2 as well as CXCR1 via both mechanisms. First, CXCR2 was cross-phosphorylated upon C5aR and FR activation, …

Sep 11, 1998 · In neutrophils, Ca2+ mobilization by the CXCR2-specific chemokine, growth-related oncogene alpha (Groalpha), was desensitized by prior exposure to the …

mice has shown that the “atypical” complement C5a receptor 2 (C5aR2) and the atypical chemokine receptor 1 (ACKR1) expressed on endothelial cells were required for the transport …