Apr 1, 2020 · CCRL2 forms functional heterodimers with CXCR2, thereby regulating CXCR2 expression levels on neutrophils and modulating chemokine-induced, CXCR2-dependent …

May 24, 2019 · These data demonstrated that C5aR2 specifically transports C5a into the blood vessel lumen to induce neutrophil arrest, whereas ACKR1 specifically transports CXCR2 …

May 10, 2019 · Transported C5a was required to initiate C5aR1-mediated neutrophil arrest, whereas transported chemokines were required to initiate CXCR2-dependent neutrophil …

CXCR2 is key stimulant of immune cell migration and recruitment, especially of neutrophils. Alleviating excessive neutrophil accumulation and infiltration could prevent prolonged tissue …

Recently, a complementary component C5a that is a chemoattractant, but not a chemokine, can be a new promising target for vasculitis. In fact, the C5a receptor inhibitor looks very promising …

CXCR1 and CXCR2 are cross-phosphorylated and desensitized to CXCL8 by receptors for N-formylated peptides (fMLP) or complement cleavage product C5a 60, 78. fMLP and C5a are …

Oct 1, 2002 · After phagocytosis of opsonized yeast, the expression of CXCR1 and CXCR2 was substantially down-regulated and was accompanied by reduced Ca ++ responses to …

Sep 11, 1998 · In neutrophils, Ca2+ mobilization by the CXCR2-specific chemokine, growth-related oncogene alpha (Groalpha), was desensitized by prior exposure to the …

May 24, 2019 · Intravital multiphoton imaging studies revealed that C5a, bound to heparan sulfate proteoglycans (HSPGs) on the luminal site of blood vessel ECs, activates C5a receptor 1 …

Oct 12, 2022 · Using Cxcr2 knock-out mice, we have evaluated the function of the chemokine receptor Cxcr2 in neutrophil physiology. We show here that Cxcr2 deficiency decreases the …