
Stromal cell-derived factor 1 - Wikipedia
The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. [5] It is ubiquitously expressed in many tissues and cell types. [6]
CXCL12 Gene - GeneCards | SDF1 Protein | SDF1 Antibody
Dec 24, 2024 · CXCL12 (C-X-C Motif Chemokine Ligand 12) is a Protein Coding gene. Diseases associated with CXCL12 include Human Immunodeficiency Virus Type 1 and Ischemia. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.
The chemokines CXCL8 and CXCL12: molecular and functional …
Feb 1, 2023 · CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12, which retains leukocytes in bone marrow. CXCL12 is primarily a homeostatic chemokine that induces migration and...
The unique structural and functional features of CXCL12
Oct 30, 2017 · The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or...
The unique structural and functional features of CXCL12
The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration of hematopoietic progenitor and …
CXCL12/CXCR4: a symbiotic bridge linking cancer cells and
May 11, 2015 · In this article, we review our current understanding of the CXCL12/CXCR4 axis in cancer tumorigenesis and progression and discuss its therapeutic implications.
CXCL12 Derived From ACKR1 + Intraplaque Neovessels Mediates …
Feb 24, 2025 · Döring Y, van der Vorst EPC, Duchene J, Jansen Y, Gencer S, Bidzhekov K, Atzler D, Santovito D, Rader DJ, Saleheen D, et al. CXCL12 derived from endothelial cells promotes atherosclerosis to drive coronary artery disease.
Recent Advances in CXCL12/CXCR4 Antagonists and Nano-Based …
In this review, we first summarize the mechanisms that mediate the physiological effects of the CXCL12/CXCR4 axis. Then, we describe the use of CXCL12/CXCR4 antagonists. Finally, we discuss the use of nano-based drug delivery systems …
The chemokine CXCL12 regulates monocyte-macrophage differentiation and ...
Jan 6, 2011 · We show that primary blood monocytes secrete the CXCL12 chemokine, and express the CXCR4 and CXCR7 receptors, leading to an autocrine/paracrine loop that contribute to shape monocyte differentiation to a distinct type of macrophages, with an enhanced expression of CD4, CD14, and CD163, or dendritic cells, with a reduced functional ability to sti...
Stromal cell-derived factor-1 (CXCL12) and its role in bone and …
Nov 1, 2019 · CXCL12 is a small chemotactic signaling protein that acts mainly through specific G-coupled protein receptor (GCPR), CXCR4, promoting downstream effects required to maintain tissue integrity and to recruit new building blocks for repair and regrowth [14].
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