Low or absent CD127 cell surface expression in combination with CD25 expression is an important and long-established marker to aid the distinction of Treg from T effector (Teff) cells …

Feb 18, 2021 · Here, we analyze Treg clonal origin in breast cancer patients using T-Cell Receptor and single-cell transcriptome sequencing. While Treg in peripheral blood and breast …

Methods: To characterize the phenotype of KLRG1/CD127-defined CD8 + subsets, surface and intracellular markers were measured by flow cytometry and Cytometry by time of flight …

Tmpec cells have potential for survival, self-renewal, proliferation, and cytokine production (7–9), whereas Teff cells produce high levels of cytolytic effector proteins [granzymes A and B …

CD4+ T cell populations were identified by high expression of CD4 and low side scatter, and Treg and Teff were identified within the CD4+ T cell population as CD25+CD127- and …

Some Teff, such as CD8+ CD27-CD43-T cells, which include both CD127+ and CD127- populations, decay more slowly [22, 96, 120] creating the biphasic decay curve typically …

In this study, Chen et al. define an effector (Teff) versus exhausted (Tex) CD8 T cell binary-fate decision during chronic infection and find that TCF-1 supports the Tex precursor development …

Dec 20, 2016 · At the Teff stage, differential expression of KLRG1 (killer cell lectin-like receptor G1) and CD127 is commonly used to identify differentiation states that differ in their propensity …

Aug 15, 2020 · Our work challenges the concept that the KLRG1 + CD127 low population is dominated by short-lived cells and shows that KLRG1 downregulation is not a prerequisite to …

Apr 15, 2008 · The CD127 (+)CD25 (low/-) subset includes IL-2-producing naive and central memory T cells; the CD127 (-)CD25 (-) subset includes mainly effector T cells expressing …