The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein [5] in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding.

CD80 is a protein that plays a crucial role in immune responses by interacting with CD4 T cells to fully activate them, increase the expression of co-stimulatory molecules, release pro-inflammatory cytokines, and license dendritic cells to activate CD8 T cells. You might find these chapters and articles relevant to this topic. Raul Elgueta, ...

The costimulatory molecule cluster of differentiation (CD) 80, which can be expressed on antigen-presenting cells (APCs) or tumor cells, interacts with both costimulatory (CD28) and coinhibitory (cytotoxic T-lymphocyte antigen 4 (CTLA-4)) receptors and regulates the immune response [1,2].

Current perceptions are based around the concept that CD86 is the initial co-stimulatory ligand based on its more abundant and earlier expression pattern; CD80 has a role following antigen-presenting-cell activation.

CD80, also known as B7-1, is generally expressed on antigen-presenting cells (APCs) in steroid-sensitive MCD patients. Various glomerular disease models associated with proteinuria demonstrated that the detection of CD80 with the increase of urinary CD80 was strongly associated closely with frequent-relapse MCD patients.

CD80 (Cluster of differentiation 80), also known as B7-1, is a type I transmembrane protein belonging to the immunoglobulin superfamily. It has an extracellular immunoglobulin constant-like domain and a variable-like domain crucial for receptor binding.

Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown. In this study, we aimed to investigate the role of CD80 both clinically and molecularly in breast cancer at a …

Dec 24, 2024 · CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia and Lymphocytic Choriomeningitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

May 3, 2021 · Receptor for Hepatitis C Virus E2 protein in B cells (J Virol 2006;80:8695) Also required for Plasmodium falciparum infectivity ( Nat Med 2003;9:93 ) Upregulation on HIV1+ B cells may ultimately cause lymphoproliferative disorders ( Clin Exp Immunol 2007;147:53 )

Oct 23, 2024 · CD80 is a critical immune checkpoint molecule that plays an essential role in T cell activation through co-stimulatory pathways. Expressed primarily on antigen-presenting cells (APCs) such as dendritic cells, B cells, and macrophages, CD80 interacts with receptors on T cells to regulate immune responses.