Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis, the process in which primordial follicles develop into pre-ovulatory follicles.

Dec 24, 2024 · BMP15 (Bone Morphogenetic Protein 15) is a Protein Coding gene. Diseases associated with BMP15 include Ovarian Dysgenesis 2 and 46 Xx Gonadal Dysgenesis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

Bone morphogenetic protein 15 (BMP15) acts as a BMP and Wnt inhibitor during early embryogenesis. These findings support the concept that an adequate amount of BMP15 secreted in the follicular fluid is critical for female fertility.

Apr 29, 2005 · The oocyte factor, bone morphogenetic protein-15 (BMP-15) has proven to be critical for normal fertility in female mammals. The biological functions of recombinant BMP-15 demonstrate its capacity to promote granulosa cell processes involved in early follicle growth, while simultaneously acting to restrict follicle-stimulating hormone (FSH ...

Bone morphogenetic protein 15 (BMP15), located on Xp11.2, is an oocyte growth factor that stimulates folliculogenesis and granulosa cell (GC) growth, and has been implicated in POI. From: Sperling Pediatric Endocrinology (Fifth Edition), 2021

Bone morphogenetic protein 15 (BMP15) belongs to an unusual subgroup of the transforming growth factor β (TGFβ) superfamily of signaling ligands as it lacks a key cysteine residue in the mature region required for proper intermolecular dimerization. ...

Nov 2, 2024 · Title: Bone morphogenetic protein 15 induces differentiation of mesenchymal stem cells derived from human follicular fluid to oocyte-like cell. Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with …

Mar 8, 2023 · Bone morphogenetic protein 15 (BMP-15) is a member of the transforming growth factor-beta (TGF-β) superfamily. This oocyte growth factor is essential for the first phases of follicle development.

Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa). Ovarian physiology and fertility are controlled by endocrine and paracrine signals.

We found that BMP-15 is a potent stimulator of GC proliferation, and importantly, the mitogenic effect was follicle-stimulating hormone (FSH)-independent. By contrast, BMP-15 alone had no effect on steroidogenesis.