C57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease.

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

The C57BL/6 mouse is a multipurpose model that can be used for research into physiology, immunology, safety and efficacy, oncology and genetics, as well as mouse model creation. B6 mice are often preferred to other inbred mice in certain research disciplines such as …

C57BL/6J is the most widely used inbred mouse strain and the first to have its genome sequenced. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss.

Jun 22, 2016 · Since C.C. Little (the founder of The Jackson Laboratory) initially generated the C57BL inbred strain in the 1920’s-1930’s, the inbred substrain C57BL/6 became the most frequently used mouse strain in biomedical research.

The C57BL/6 mouse is a multipurpose model that can be used in such fields as model creation, physiology, safety and efficacy, and genetics. General Purpose - Atochina, E.N. et al. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization.

Mar 30, 2020 · In C57BL/6 mice, Th1 immune response and IFNγ production play the key role. Alternately, it is easier to induce Th2 immune response in BALB/c mice, which is very common in infectious diseases and allergic reactions. BALB/c mice tend to produce a stronger humoral response than C57BL/6 mice.

In this retrospective study, we screened data from more than 12,000 mice phenotyped in the German Mouse Clinic from January 2006 through June 2014 and selected animals with the genetic background of C57BL/6J, C57BL/6N, or C3HeB/FeJ. In addition, we distinguished between the C57BL/6NTac substrain and C57BL/6N mice received from other vendors.

We analyzed the substrain status of 2,939 genetically modified C57BL/6 mice deposited at the RIKEN BioResource Research Center (BRC) (Fig. 2). Each substrain was further subdivided into substrains supplied by several vendors.

C57BL/6 mice are inbred mice developed by C.C. Little in 1921 at The Bussey Institute for Research in Applied Biology. The C57BL/6 mice are used for transgenic and knockout model development (the wild-type C57BL/6 mice are a good control), as well as, obesity and immunological studies.

The C57BL/6 (B6) mouse strain is the most widely used strain in biomedical research, with nearly 25,000 articles on Pubmed documenting its use. Nearly half of these articles cite the use of C57BL/6J (B6/J), the original B6 strain from the Jackson Laboratory (JAX) from which all other B6 substrains were derived.

The Black 6 (B6) mouse model is one of the most reliable and consistent inbred strains used in biomedical research. Known for its uniform genetic makeup, the C57BL/6 strain is ideal for researchers who require highly reproducible results across experiments.

Dec 10, 2024 · View mouse strain C57BL/6 : mutations, QTL, phenotypes, diseases, and references.

Sep 12, 2017 · C57BL/6NTac mice are prone to developing diet-induced obesity and insulin resistance when fed a high fat diet. Increased adiposity when maintained on an 11% fat diet would not be surprising. Taconic's standard chow is the NIH 31M formula .

These efforts have been conducted using a standardized C57BL/6N embryonic stem cell line, given the many advantages of using an inbred ES cell strain in GEMM production, as well as the marked differences in assay responses that can be …

C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss (this strain is homozygous for Cdh23 ahl). They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

Here are three ways in which B6J mice differ from B6N mice: 1. Mice on the C57BL/6N genetic background carry the Crb1 mutation. Photoreceptor degeneration is observed in spots, caused by retinal folds and pseudorosettes, found in the fundus of the eye of all vendor lines of the C57BL/6N line (Mattapallil et al. 2012).

Sep 28, 2023 · Learn about finding and selecting mouse models, the basics of mouse nomenclature, the importance of choosing the appropriate controls for your experiment, and how genetic drift affects your colony. In this webinar, we cover the considerations for choosing and using the most appropriate B6 substrain for your research needs.

Perhaps no strain of mouse exemplifies this best than a highly inbred mouse strain known as C57BL/6, sometimes abbreviated to “black 6” or B6. This dark-furred rodent is sensitive to pain and cold, likes to drink alcohol when offered it, and tends to suffer from atherosclerosis and age-related hearing loss.

The C57BL/6 mouse strain, commonly known as the “Black 6” or the “C57” mouse, is renowned for its ubiquity in genetic research. This strain is characterized by their dark, glossy coats, hence the moniker “Black 6”.