Aug 24, 2010 · Our approach provides a new view of RTK and Akt–RSK–S6 kinase signaling, revealing previously unidentified Akt–RSK–S6 kinase substrates that merit further consideration as targets for combination therapy with RTKIs.

Background: The mammalian target of rapamycin (mTOR) controls cell growth through protein synthesis regulation. It can be activated by protein kinase B (AKT) or through ribosomal S6 kinase (S6K1).

A focused view of Akt-RSK-p70 S6 Kinase Signaling. This study provides a large-scale identification and analysis of substrates phosphorylated by the Akt, RSK, and S6 family of protein kinases.

Mar 22, 2022 · Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), directly...

Jul 25, 2022 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been canonically assigned for cell...

Nov 3, 2008 · Here, we set out to study the interplay between Akt and S6K in the regulation of pancreatic β cell growth and function. In addition, we address whether the constitutive activation of Akt/mTORC1/S6K may cause oncogenic transformation of β cells.

Nov 8, 2004 · Akt-directed phosphorylation of tuberin relieves its inhibition of TOR, via activation of the small G protein Rheb (not depicted). TOR activation by this pathway requires the presence of nutrients and results in activation of S6K and inhibition of 4E-BP1.

Apr 1, 2011 · In the present study, we have examined the effects of S6K2 on Akt activation and cell survival. Silencing of S6K1 caused a modest decrease whereas knockdown of S6K2 caused a substantial increase in tumor necrosis factor-α (TNF)- and TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.

Oct 22, 2024 · In this study, we revealed that the triple targeting of RSK, AKT, and S6K by TAS0612 leads to the modulation of various pathophysiologically and clinically important molecules in HMCLs.

Nov 8, 2004 · Proper regulation of the phosphoinositide 3-kinase-Akt pathway is critical for the prevention of both insulin resistance and tumorigenesis.