Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. [5][6][7] ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor.

Dec 24, 2024 · ACVR2A (Activin A Receptor Type 2A) is a Protein Coding gene. Diseases associated with ACVR2A include 2Q23.1 Microduplication Syndrome and Fibrodysplasia Ossificans Progressiva. Among its related pathways are Signaling by TGFB family members and Signaling by NODAL.

There are two activin type two receptors: ACVR2A and ACVR2B. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type 2 receptor, which recruits and trans-phosphorylates a type I receptor.

Feb 8, 2025 · Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

Aug 18, 2017 · Here, we generated mice with conditional deletion of activin receptor (ACVR) type 2A, ACVR2B, or both, in osteoblasts, to determine the contribution of activin receptor signaling in regulating bone mass. Immunohistochemistry localized ACVR2A and ACVR2B to …

ACVR2A, located at 2q22.3-q23.1, consists of 12 exons and encodes activin A type 2A receptor that mediates the function of inhibin A, activin A, activin B, and myostatin. As a putative candidate gene, ACVR2A is a cell-signaling protein known as a significant regulator of reproductive function (Fitzpatrick et al. 2009 ; Yanan et al. 2020 ).

Disruptions of the receptor function in the TGF-β/activin signaling pathway can be caused by rare mutations of the tumor suppressor genes ACVR1Bon chromosome 12q, ACVR2A on chromosome 2q, TGFBR1on chromosome 9q, and TGFBR2 on chromosome 3p.

Jan 4, 2025 · Title: Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

Feb 8, 2025 · Go to Variation Viewer for ACVR2A variants Summary This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes.

BMPR2 is a type II Transforming Growth Factor (TGF)-β family receptor that is fundamentally associated with pulmonary arterial hypertension (PAH) in humans. BMPR2 shares functional similarities with the type II activin receptors ACVR2A and ACVR2B, ...