
APOBEC3G - Wikipedia
APOBEC3G exerts innate antiretroviral immune activity against retroviruses, most notably HIV, by interfering with proper replication. However, lentiviruses such as HIV have evolved the Viral infectivity factor (Vif) protein in order to counteract this effect.
APOBEC - Wikipedia
APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide") is a family of evolutionarily conserved cytidine deaminases. A mechanism of generating protein diversity is mRNA editing. The APOBEC family of proteins perform mRNA modifications by deaminating cytidine bases to uracil.
The implications of APOBEC3-mediated C-to-U RNA editing for …
May 4, 2024 · APOBEC3-mediated RNA editing sites have been found in genes with known relationships to neoplasms, hypertension, and nervous system disorders, including amyotrophic lateral sclerosis (ALS ...
APOBEC3 Proteins in Viral Immunity - PMC - PubMed Central (PMC)
Here we review the data regarding the various steps in the innate and adaptive immune response to virus infection in which APOBEC3 proteins have been implicated. The genomes of mammals and other species contain many genes that restrict infection by viruses.
APOBEC3B regulates R-loops and promotes transcription ... - Nature
Sep 21, 2023 · Biochemical experiments show APOBEC3B binding to R-loops in cells and in vitro. Genetic experiments demonstrate R-loop increases in cells lacking APOBEC3B and decreases in cells overexpressing...
The spectrum of APOBEC3 activity: from anti-viral agents to anti …
The APOBEC3 family of cytosine deaminases are part of the innate immune response to viral infection, but also have the capacity to damage cellular DNA. Detection of mutational signatures consistent with APOBEC3 activity, together with elevated ...
Human APOBEC3 Variations and Viral Infection - PMC
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes are capable of inhibiting a wide range of endogenous and exogenous viruses using deaminase and deaminase-independent mechanisms.
APOBEC3-mediated mutagenesis in cancer: causes, clinical …
Mar 28, 2023 · The resulting mutations, primarily signatures 2 and 13, occur in many tumor types and are among the most common mutational signatures in cancer. This review summarizes the current evidence implicating APOBEC3s as major mutators and outlines the exogenous and endogenous triggers of APOBEC3 expression and mutational activity.
Mechanisms of APOBEC3 mutagenesis in human cancer cells
Jul 20, 2022 · Endogenous APOBEC3 deaminases generate prevalent mutational signatures in human cancer cells, and APOBEC3A is the main driver of these mutations.
Mechanisms of APOBEC3 mutagenesis in human cancer cells
Our results identify APOBEC3A as the main driver of these mutations, indicate that APOBEC3B can restrain APOBEC3A-dependent mutagenesis while contributing its own smaller mutation burdens and dissect mechanisms that translate APOBEC3 …