Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. [5][6][7] ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.

Dec 24, 2024 · ACVR2B (Activin A Receptor Type 2B) is a Protein Coding gene. Diseases associated with ACVR2B include Heterotaxy, Visceral, 4, Autosomal and Visceral Heterotaxy. Among its related pathways are Akt Signaling and Signaling by TGFB family members.

There are two activin type two receptors: ACVR2A and ACVR2B. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type 2 receptor, which recruits and trans-phosphorylates a type I receptor.

Feb 8, 2025 · Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. We found that the AAAAA, AGGAG, and AGGGA haplotypes in ACVR2B were associated with susceptibility to Premature Ovarian Failure when they also had at least one CATAG haplotype in ADAMTS19.

Activin receptor type IIB (Acvr2b) mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, Bmp7, Gdf1, Gdf3, Myostatin (Gdf8), and Gdf11.

May 16, 2006 · Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c).

Title: MicroRNA-194 protects against chronic hepatitis B-related liver damage by promoting hepatocyte growth via ACVR2B. Study supported ACVR2B as the facilitator for clear cell kidney carcinoma (KIRC) development.

Dec 10, 2024 · Clinical resource with information about ACVR2B, Genetic determinants of P wave duration and PR segment., Heterotaxy, visceral, 4, autosomal, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Jan 17, 2006 · ACVR2B contains an extracellular ligand binding domain, a transmembrane domain, and an intracellular serine/threonine kinase domain. Northern blot analysis of fetal tissues revealed that ACVR2B mRNAs are variably expressed in several tissues, with the highest level of expression in brain.

Mar 6, 2025 · Background lncRNAs are key regulators in thyroid cancer (TC). While lncRNA ACVR2B-AS1 has been proposed as a potential TC biomarker, its role remains underexplored. This study aims to clarify its clinical significance in TC and investigate its molecular mechanism. Materials and methods qRT-PCR was used to assess the expression of ACVR2B-AS1 in TC tissues and cell lines. Kaplan–Meier survival ...