Three-dimensional real time imaging of amyloid β aggregation …
Jun 16, 2020 · In this study, we successfully visualized real-time process of Aβ 42 aggregation around living cells by applying our established QD imaging method. 3D observations using …
Amyloid beta: structure, biology and structure-based …
Jul 17, 2017 · In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, …
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
Aug 30, 2021 · Here, we systematically review and update the vast state-of-the-art literature of Aβ science with evidence from basic research studies to human genetic and multi-modal …
2BEG: 3D Structure of Alzheimer's Abeta(1-42) fibrils - RCSB PDB
Oct 24, 2005 · Here, we present the 3D structure of the fibrils comprising Abeta (1-42), which was obtained by using hydrogen-bonding constraints from quenched hydrogen/deuterium …
3D dynamic tracking Aβ plaques in live brains using vinyl-bridged …
Oct 15, 2023 · Notably, using WAPP-4, we achieved in vivo 3D dynamic imaging of Aβ plaques in the brains of living mice with Alzheimer's disease (AD). In addition, super-resolution imaging …
High-Resolution 3D Reconstruction Reveals Intra-Synaptic …
Nov 1, 2011 · β-Amyloid (Aβ) accumulation and aggregation are hallmarks of Alzheimer's disease (AD). High-resolution three-dimensional (HR-3D) volumetric imaging allows for better analysis …
3D structure of Alzheimer's amyloid-β (1–42) fibrils - PMC
Nov 11, 2005 · Here, we combined the available structural information on Aβ(1–42) fibrils with detailed amide hydrogen-exchange measurements, pairwise mutagenesis, thioflavin T (ThioT) …
6SZF: Solution structure of the amyloid beta-peptide (1-42)
Oct 2, 2019 · Aβ(1-42) structure was solved by us, giving evidence that the evolution of Aβ(1-42) peptide from helical to the β-sheet may follow unexpected routes. Molecular dynamics …
Non-invasive visualization of amyloid-beta deposits in Alzheimer ...
Here, we utilized a fluorescence molecular tomography (FMT)-magnetic resonance imaging (MRI) pipeline with the curcumin derivative fluorescent probe CRANAD-2 to achieve full 3D brain …
Recapitulating amyloid β and tau pathology in human neural cell …
Nov 2, 2015 · We recently developed a human neural cell culture model of AD based on a three-dimensional (3D) cell culture system. This unique, cellular model recapitulates key events of …