The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5]

This repeat length variant in the promoter region of this gene has been shown to affect the rate of serotonin uptake and may play a role in post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

Jan 2, 2018 · Presence of the short (‘s’) allele of 5-HTTLPR reduces in vitro gene transcription and transporter activity compared with the long (‘l’) allele, resulting in increased synaptic levels of serotonin. In this study, presence of stressful life events was associated with an increase in risk of depression in heterozygous individuals and in ...

May 13, 2019 · Specifically, many scientists focused on the so-called 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene to research the effects of this gene on depression.

5-HTT: The Gene for Susceptibility to Depression? A recent scientific paper and a corresponding popular press report announced that mutations in the 5-HTT gene moderate a person's likelihood to experience depression after stressful events (Caspi et. al., 2003).

Sep 30, 2023 · The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by regulating extracellular brain serotonin levels; it remains unclear to what extent 5-HTT levels in the human...

Serotonin (5-HT) regulates important biological and psychological processes including mood, and may be associated with the development of several psychiatric disorders. An association between psychopathology and genes that regulate 5-HT neurotransmission is a robust area of research.

Feb 11, 2021 · The serotonin transporter (5-HTT) encoded by SLC6A4 is a key molecule that regulates serotonergic neurotransmission at the synaptic cleft, affecting emotions and stress responses. Therefore ...

The serotonin transporter gene promoter variant, consisting of a long (L) and a short (S) variant, is one of the major factors which contribute to the etiology of many psychiatric disorders.

Jul 18, 2003 · In this study, a functional polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) was used to characterize genetic vulnerability to depression and to test whether 5-HTT gene variation moderates the influence of life stress on depression.