2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP 3 receptors [1] and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).

A cell-permeable modulator of Ins(1,4,5)P 3-induced Ca 2+ release. Inhibits Ins(1,4,5)P 3-induced Ca 2+ release from rat cerebellar microsomal preparations (IC 50 = 42 µM) without affecting [3 H]-Ins(1,4,5)P 3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca 2+ channels through a mechanism which may involve its binding to either the channel protein or an associated ...

Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals.

Mar 2, 2020 · In this study we report that 2-aminoethoxydiphenylborate (2-APB) significantly inhibits the release of PS-exposing EVs from platelets stimulated with the Ca 2+ ionophore, A23187, or the...

2-Aminoethyl diphenylborinate. (C6H5)2BOCH2CH2NH2. Synonyms: 2-APB, 2-Aminoethoxydiphenyl borate, 2-Aminoethyl diphenyl borate, Diphenylboric acid 2-aminoethyl ester, Diphenylborinic acid, NSC 17107. CAS 524-95-8. Molecular Weight 225.09. Browse 2-Aminoethyl diphenylborinate and related products at MilliporeSigma.

2-aminoethoxydiphenyl borate (2-APB) is commonly used as a tool to modulate calcium signaling in physiological studies. 2-APB has a complex pharmacology and acts as activator or inhibitor of a variety of Ca 2+ channels and transporters.

Cell-permeable, allosteric inhibitor of D-*myo*-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry. Be the first to review this product! Submit a review.

2-Aminoethyl diphenyl borinate (2-APB) is a membrane-permeant, lipophilic compound that was originally described as a blocker of intracellular inositol 1,4,5 trisphosphate [Ins (1,4,5) P3] receptors. 1,2 Soon afterwards, it was discovered that this compound can block store-operated calcium channels in various cell types without engaging the Ins ...

Jun 2, 2004 · Here, we demonstrate that 2-aminoethoxydiphenyl borate (2-APB), a compound used to inhibit store-operated Ca2+ channels and IP3 receptors, produces robust activation of recombinant TRPV3 in human embryonic kidney 293 cells with an EC50 of 28 microm. 2-APB also sensitizes TRPV3 to activation by heat, even at subthreshold concentrations.