Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene. [3] [4] CCL8 is a small cytokine belonging to the CC chemokine family.

May 2, 1997 · Monocyte chemotactic protein (MCP)-2 is a member of the C-C chemokine subfamily, which shares more than 60% sequence homology with MCP-1 and MCP-3 and about 30% homology with macrophage inflammatory protein (MIP)-1alpha, regulated on activation of normal T cell expressed (RANTES), and MIP-1beta.

May 2, 1997 · Monocyte chemotactic protein (MCP)-2 is a member of the C-C chemokine subfamily, which shares more than 60% sequence homology with MCP-1 and MCP-3 and about 30% homology with macrophage inflammatory protein (MIP)-1α, regulated on activation of normal T cell expressed (RANTES), and MIP-1β.

The monocyte chemotactic proteins (MCP-1, MCP-2, and MCP-3) showed a typically bimodal concentration dependence, and were considerably more effective than MIP-1 alpha, MIP-1 beta, or RANTES. All CC chemokines also induced a rapid and transient rise in cytosolic free Ca2+ in either type of T cell.

A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 2 (MCP-2), a secreted chemokine that is chemotactic for monocytes, lymphocytes, basophils and eosinophils. MCP-2/CCL8 is structurally related to the CXC subfamily of cytokines, and characterised by two cysteines separated by a single amino acid.

The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family.

Know comprehensive MCP-2/CCL8 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Feb 4, 2009 · CCL8 or monocyte chemoattractant protein (MCP)-2 is a CC chemokine that mainly attracts monocytes and T cells and MCP-2 mRNA is upregulated in monocytes following infection by M. tuberculosis.

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Many chemokines, such as monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1α) and beta (MIP-1β), and Regulated on Activation Normal T cell Expressed and Secreted protein (RANTES), effect their function through ligand binding with a C-C chemokine receptor.