Dec 25, 2024 · PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PIK3CA include Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome and Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi.

The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO -approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit.

Aug 15, 2013 · PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia.

The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). Learn about this gene and related health conditions.

Mar 1, 2024 · One type of gene mutation that’s known to affect people with breast cancer is called PIK3CA. A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. It contributes...

Perhaps one of the most interesting and surprising recent findings in the PIK3CA field was the recent report of common hotspot mutations of PIK3CA in two benign skin lesions – epidermal nevi and seborrheic keratoses (SK), two noninvasive keratinocyte-derived skin tumors.

The PIK3CA protein mediates signaling by many cell surface hormone or growth factor receptors, including insulin and insulin-like growth factor 1 (IGF1). Pathologically activated PIK3CA may thus mimic insulin and/or IGF1 action.

May 15, 2019 · In a randomized, phase 3 trial, we compared alpelisib (at a dose of 300 mg per day) plus fulvestrant (at a dose of 500 mg every 28 days and once on day 15) with placebo plus fulvestrant in patients...

PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis.

Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway. NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma.