Complement C3 knockout protects photoreceptors in the sodium …
Jan 1, 2025 · Iba1 and CD11b levels were significantly increased in both NaIO 3-treated groups, providing no evidence for a difference in mononuclear phagocyte recruitment or activation.
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the ...
(B) Flat mounts of the retina stained with Iba1 demonstrate that NaIO3 exposure results in marked increase in positive-staining cells that is reduced by Met12, but not mMet12, treatment. The …
Monocyte infiltration and proliferation reestablish myeloid cell ...
Aug 16, 2017 · Among endogenous retinal microglia (Iba1+, tdTomato+), we found that multiple cells were also Ki67+, with a lower prevalence in the GCL (≈40%) than in the IPL and OPL …
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal ...
Feb 18, 2020 · The decreased Iba1+ staining and photoreceptor degeneration we observed in TLR2-deficient mice after treatment with NaIO 3 supports the existence of a TLR2-driven …
Complement C3a receptor inactivation attenuates retinal …
Triple immunostaining of CD68, C3 and Iba1 revealed the characteristics of microglial phenotypes. Oxidative stress induced an increase in the number of CD68-positive phagocytic …
Sodium Iodate-Induced Degeneration Results in Local …
After ten days, the outer segments were almost completely degraded, and no IBA1-positive cells were present in this region anymore. Müller cell gliosis at day 10 was a consequence in the …
Expression of a CARD Slows the Retinal Degeneration of a …
Indeed, Xiao and colleagues 33 have recently shown an influx of Iba1-positive monocytic cells in the outer retinas of rats treated systemically with NaIO3. This group also showed that …
NaIO3 (40 mg/kg) induced inflammatory response in RPE
NaIO3 (40 mg/kg) induced inflammatory response in RPE monolayer after 3 days. (a) Representative immunofluorescence images of Iba1 staining in RPE monolayer of mice (50x …
NaIO3-induced RPE injury induced early mobilization of …
This was associated with elevated levels of DNA damage, PARP-mediated NAD+ consumption, and migration of Iba1+/CD45+ microglia/macrophages to the subretinal space in the retinas of...
NaIO3 (40 mg/kg) induced inflammatory response in RPE
Abbreviations: Iba1: ionized calcium-binding adapter molecule 1; Zil: Zileuton. from publication: 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced ...