MAPK14 encodes p38α mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. p38 MAPKs are also known as stress-activated serine/threonine-specific kinases (SAPKs).

Dec 25, 2024 · MAPK14 (Mitogen-Activated Protein Kinase 14) is a Protein Coding gene. Diseases associated with MAPK14 include Chlamydia and Coffin-Lowry Syndrome. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

Mar 8, 2025 · MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines.

Jan 27, 2021 · p38 kinases are proline-directed serine/threonine kinases of the mitogen -activated protein kinase (MAPK) family, which are found in all eukaryotes and whose structural and regulatory...

Mar 5, 2021 · P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and cancer. Inhibitors of p38α can be utilized for treatment of these diseases.

To investigate whether Mapk14 expression can be used as a prognostic marker for colorectal cancer patients, we evaluated the distribution of Mapk14 expression levels and its relationship with patient Disease-free survival (DFS) and Disease Specific Survival (DSS) using the GSE17537 dataset.

Jan 22, 2025 · MAPK14 can be activated by phosphorylation and enters the nucleus, where it activates transcription by phosphorylating transcription p53. Here, we identified MAPK14 as the target protein of lobeline, and MAPK14 inhibited the …

Feb 11, 2025 · Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of cell differentiation; and skeletal system development.

Feb 9, 2025 · Clinical resource with information about MAPK14, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Aug 28, 2023 · Also known as p38, MAPK14 is activated in response to cellular stress and it can phosphorylate a number of transcription factors. It is also involved in the production of IL6 , and is an important player in cellular senescence .