Naive T lymphocytes are typically positive for CD45RA, which includes only the A protein region. Activated and memory T lymphocytes express CD45RO, the shortest CD45 isoform, which lacks all three of the A, B, and C regions.

Feb 7, 2025 · CD45RA, a splice variant of the CD45 protein, is a transmembrane glycoprotein encoded by the PTPRC gene. Its unique extracellular domain, composed of fibronectin type III repeats, is crucial for its function as a receptor-type protein tyrosine phosphatase.

CD45RA T cells have "naive" characteristics of unresponsiveness to recall antigens and prominence in cord blood, while CD45RO T cells are considered "memory" T cells because they proliferate to recall antigens and increase following PHA activation of cord blood.

The present study demonstrates that CD45RA and CD45RO are regulated in inflammation in a cell-specific manner, as evidenced in volunteers, surgical patients, and patients with sepsis, as well as in ex vivo LPS-treated samples.

Nov 1, 2006 · We studied the time course of CD45RA and CCR7 expression on human antitumoral cytotoxic T lymphocyte (CTL) clones and blood CD8 + T cells after antigenic stimulation.

Nov 13, 2017 · However, a subset of effector memory T cells re-expresses CD45RA (termed TEMRA) after antigenic stimulation with unknown molecular characteristics and functions. CD4 TEMRA cells have been...

3 days ago · CD45 isoforms [functionally similar proteins with similar but not identical amino acid sequence], including CD45A, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule (J Exp Med 1987;166:1548)

CD45RA contains exon 4 but lacks exon 5 and 6. It's expressed on naïve T cells. CD45RO contains exon 3, 7 and 8 and lacks the RA, RB and RC exons of the CD45 gene. CD45 isoforms with short extracellular domains homodimerize more …

We have investigated the differences in the proximal signaling induced by anti-CD3 monoclonal antibody in purified populations of "naive" CD45RA+ and "memory" CD45RO+ human CD4+ T cells. Expression of cell surface CD3, CD4 and CD28 was …

CD45RA is expressed on leukaemic cells in the majority of AML patients. We investigated the potency of CD45RA to specifically identify LSC and HSC and improve LSC quantification. Compared to our best other markers (CLL-1, also termed CLEC12A, CD33 and CD123), CD45RA was the most reliable marker.