Recently, CD244 has been highlighted as a surface antigen to distinguish PMN-MDSCs from normal neutrophils (11,16–18). Here, CD244 is an immunoregulatory transmembrane receptor …

Nov 27, 2018 · CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types—including NK cells, a subset of …

Moreover, G-MDSC have shown a higher immunosuppressive activity, expressed higher levels of CD115 and CD244, and lower levels of CXCR1 than PMN [61,73]. G-MDSC exerted less …

Moreover, CD244 was increased on intratumoral DC and MDSC and high CD244 expression correlated with PD-L1 expression and increased spontaneous expression of immune …

Here, we assess the therapeutic potential of CD244 (2B4/signaling lymphocyte activation molecule family 4), an immunoregulatory receptor found on a variety of immune cells, …

CD115 and CD244 are expressed by subsets of PMN-MDSC infiltrating tumors and are absent on bonafide neutrophils . In addition, the buoyant properties of the murine PMN-MDSC appear …

As a result, intraperitoneal PMN‑MDSCs were found to be substantially increased in association with PD progression. Based on these results, we phenotypically and functionally verified the …

Mar 23, 2021 · Another study reported that MDSC cells that expressed CD244 were more abundant in the peripheral blood of active TB patients, and this inhibited CD4 + and CD8 + T …

Unlike neutrophils from naïve mice, splenic G-MDSC are immune suppressive and express higher levels of M-CFSR, CD244, arginase, MPO and ROS, with a lower phagocytic activity . A …

In all four tumor models, >30% of spleen and blood G-MDSC expressed the CD244 receptor (P<0.01). In the peritoneal cavity, the proportion of G-MDSC positive for CD244 was even …