Vascular endothelial growth factor A (VEGF-A) is a dimeric glycoprotein that plays a significant role in neurons and is considered to be the main, dominant inducer of the growth of blood vessels.

VEGF-A regulates angiogenesis and vascular permeability by activating 2 receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk1 in mice). On the other hand, VEGF-C/VEGF-D and their receptor, VEGFR-3 (Flt-4), mainly regulate lymphangiogenesis.

Vascular endothelial growth factor (VEGF, / vɛdʒˈɛf /), originally known as vascular permeability factor (VPF), [1] is a signal protein produced by many cells that stimulates the formation of blood vessels.

The vascular endothelial growth factor (VEGF) family of cytokines plays a key role in vasculogenesis, angiogenesis, and lymphangiogenesis. VEGF-A is the main member of this family, alongside placental growth factor (PlGF), VEGF-B/C/D in mammals, and VEGF-E/F in other organisms.

Both VEGF and VEGFRs are expressed not only on endothelial cells, but also on non-endothelial cells. This article aims to highlight the most recent data referring to the VEGF family and its receptors, as well as its implications in the angiogenesis process.

Jul 25, 2023 · Among these, vascular endothelial growth factor A (VEGFA; also known as VEGF) and its two tyrosine kinase receptors, VEGFR1 and VEGFR2, represent a key signalling pathway mediating...

Vascular endothelial growth factor (VEGF) is known to be involved in the pathophysiology of angiogenesis and vascu-largenesis including tumorigenesis, vascular permeability and metastasis. The growth factor is a 35–45 kDa homo-dimeric glycoprotein that is specific for endothelial cells.

Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, leads to endothelial cell proliferation, migration, survival and new vessel formation involved in angiogenesis.

3 days ago · This prospective study conducted in a phase 3 trial has shown that pre-treatment serum VEGF-A was a negative biomarker for PFS in patients with advanced NSCLC treated with a combination of an anti ...

Feb 20, 2025 · Gene target information for VEGFA - vascular endothelial growth factor A (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.