Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. [5] This gene encodes a member of the serine/threonine protein kinase family and the TGFB receptor subfamily.

Dec 25, 2024 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are Loss of Function of TGFBR2 in Cancer and TGF-beta receptor signaling activates SMADs.

The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.

TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain, which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex.

1 day ago · TGFBR2 is a constitutively active serine/threonine kinase receptor that binds TGF-β ligands and phosphorylates TGFBR1, initiating intracellular signaling. Unlike TGFBR1, which requires activation, TGFBR2 exhibits basal activity. Loss-of-function mutations in TGFBR2 are implicated in several cancers, including colorectal and gastric ...

Apr 29, 2021 · Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex.

Sep 8, 2024 · Go to complete Gene record for TGFBR2; Go to Variation Viewer for TGFBR2 variants; Summary. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with …

HGNC Approved Gene Symbol: TGFBR2. Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38) : 3:30,606,356-30,694,142 (from NCBI) By screening a human hepatoma cell cDNA library with a porcine TGFBR2 cDNA as probe, Lin et al. (1992) isolated a TGFBR2 cDNA encoding a deduced 567-amino acid protein.

Jan 2, 2015 · TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated that loss of Tgfbr2 expression in mammary fibroblasts was linked to tumour initiation and metastasis.

Oct 21, 2020 · Here we show that depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4 + T cells, but not CD8 + T cells, halts cancer progression as a result of tissue healing and...