S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene. [5] The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

Dec 25, 2024 · S100A9 (S100 Calcium Binding Protein A9) is a Protein Coding gene. Diseases associated with S100A9 include Juvenile Rheumatoid Arthritis and Crohn's Disease. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

S100A9 is a calcium binding protein with multiple ligands and post-translation modifications that is involved in inflammatory events and the initial development of the cancer cell through to the development of metastatic disease.

Dec 10, 2024 · S100A8/9 has been shown to be up-regulated in gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast cancer, and melanoma. 22 Survival analysis in 33 types of cancer shows that low S100A8 and S100A9 expression is associated with a longer survival time, 56 and patients with high S100A8/9 serum concentrations or S100A9 ...

S100A9 was an effective tool to predict the response of tumor patients to immune checkpoint inhibitors (ICIs). (A, B) Differential expression of immune stimulatory genes (A) and immune inhibitory genes (B) between high and low expression groups of S100A9.

Mar 8, 2025 · Title: S100A9 Exacerbates the Inflammation in Rosacea through Toll-Like Receptor 4/MyD88/NF-κB Signaling Pathway. Overexpressing S100A9 ameliorates NK cell dysfunction in estrogen receptor-positive breast cancer.

Nov 27, 2023 · As members of the S100 protein subfamily of myeloid-related proteins, S100A8, S100A9 and S100A12 play a crucial role in resisting microbial infection and maintaining immune homeostasis.

May 15, 2024 · S100A9 regulates three fundamental mechanisms contributing to lung inflammation in infection. First, it increases the number of myeloid cells in circulation. S100A9 has been shown to induce the differentiation of acute myeloid cells and their growth arrest in human and mouse models of acute myeloid leukemia .

Jan 1, 2021 · Here, we show that the calcium-dependent cytokines S100A8 and S100A9 are recruited to numerous promoters and enhancers in a model of breast cellular transformation.

S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family. Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in modulating various inflammatory responses and inflammation-associated diseases.