Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. [5]

Based on plectin’s broad interaction potential, strategic locations, and ample functional repertoire, dysfunctional plectin leads to a variety of disorders and diseases.

Here, we report on plectin’s differential gene and protein expression in cancer, explore its mutational profile, and discuss the current understanding of plectin’s and CSP’s biological function in cancer.

Feb 27, 2023 · What is plectin? Plectin is a giant cytoskeletal crosslinker (also known as a cytolinker) protein of more than 4,500 amino acids. It belongs to the plakin family of giant proteins, including desmoplakin, envoplakin and periplakin.

Aug 26, 2023 · Herein, we summarized the structure, expression and function of plectin, and mainly focused on recent studies on the functional and physical interactions between plectin and its interacting molecules, shedding light on the potential of targeting plectin for cancer therapy.

Mar 5, 2021 · Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell junctions.

Aug 24, 2024 · Here, we first introduce the molecular structure and function of plectin, and then we summarize the current understanding of the crucial role of plectin in cancer progression.

Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies.

Jun 25, 2020 · Plectin, a universally expressed multi‐functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk with actomyosin and microtubules.

Plectin, encoded by PLEC, is a highly conserved and ubiquitously expressed intermediate filament-linking protein with tissue and organelle-specific transcript isoforms that serves as a versatile linker of cytoskeletal components to target organelles in cells of different tissues. You might find these chapters and articles relevant to this topic.