Additionally, AMPK promotes lipid breakdown through regulation of lipophagy, specifically by (1): Direct phosphorylation of ULK1 to initiate autophagosome formation (2); Inhibition of mTORC1 through ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

Downstream, defects in insulin signaling result in reduced activation of mTORC1 and overactivation of FOXO proteins. In the past decade, the relationship between autophagy and insulin resistance has ...

The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry ...