Department of Nuclear Medicine, Xinqiao Hospital, Army Medical University, Chongqing 400037, China School of Medical Imaging, North Sichuan Medical College, NanChong 637100, China Department of ...

Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

In NPC1 cells, SFN induces TFEB nuclear translocation via a ROS-Ca 2+-calcineurin dependent but MTOR-independent pathway and upregulates the expression of TFEB-downstream genes, promoting lysosomal ...

The differentially activated Akt/mTOR/p70S6K pathway might involve in the host response to H5N1 viruses. Therefore, systematically integrated with datasets from primary genomic and virus titer results ...

Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...

This study explored the regulation of Akt/mTOR/p70S6K/toll-like receptor-4 (TLR-4) during an effector-induced neuronal structural and functional remodeling after a nerve transposition and aimed to ...