gut.bmj22d
Targeting mTOR dependency in pancreatic cancer
Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...
WPRI 1223d
Hoth Therapeutics Announces Positive Findings on GDNF's Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved ...
Frontiers2mon
Metabolic reprogramming and immunological changes in the microenvironment of esophageal cancer: future directions and prospects
Background: Esophageal cancer (EC) is the seventh-most prevalent cancer worldwide and is a significant contributor to cancer-related mortality. Metabolic reprogramming in tumors frequently coincides ...
eLife2y
Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway
Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...
Frontiers4y
Effects of Akt/mTOR/p70S6K Signaling Pathway Regulation on Neuron Remodeling Caused by Translocation Repair
This study explored the regulation of Akt/mTOR/p70S6K/toll-like receptor-4 (TLR-4) during an effector-induced neuronal structural and functional remodeling after a nerve transposition and aimed to ...
eLife5y
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by ...