Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

For example, ZDHHC2-mediated palmitoylation of mitochondrial acylglycerol kinase (AGK) increases sunitinib resistance in renal cell carcinoma by activating the AKT–mTOR signaling pathway ... in the ...

Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...

Iron is an essential molecule for biological processes, but its accumulation can lead to oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is implicated in the ...

Neural development is a complex, orchestrated process consists of multiple elements, including the self-renewal and differentiation of neural progenitors. Neural progenitors divide to self-renew and ...