Therefore, rapamycin appears to be exerting its antitumour effects though S6K, and thus, pS6 may be the best marker for measuring response to mTOR inhibitors ... a dramatic inhibition of ...
Methods and results Target validation assays showed significant expression of phosphorylated ribosomal protein S6 (pS6), a downstream mediator of the phosphatidylinositol 3-kinase delta (PI3Kδ) ...
The Audi S6 Avant TDI takes to the road with a high-torque V6 TDI engine, offering customers in Europe ideal performance for long-distance driving. The S sports suspension with damper control, dynamic ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. m 6 A RNA modification has been linked to ...
With mTOR inhibitors, we could assess activity in terms of downregulation of phosphorylation of proteins, including p70 S6K, and functionally in terms of cell proliferation. Indeed, several ...
Furthermore, a combination of WDR5 targeting with mTOR inhibitors leads to potent suppression of translation and proliferation of breast cancer cells. These results reveal novel therapeutic strategies ...
Background: Bladder carcinoma (BC) is one of the most prevalent and malignant tumors. Multiple gene signatures based on BC metabolism, especially regarding glycolysis, remain unclear. Thus, we ...
This study explored the regulation of Akt/mTOR/p70S6K/toll-like receptor-4 (TLR-4) during an effector-induced neuronal structural and functional remodeling after a nerve transposition and aimed to ...
In this study, we show that ZNRF2 interacts with mTOR on membranes, promoting the amino acid-stimulated translocation of mTORC1 to lysosomes and its activation in human cells. ZNRF2 also interacts ...
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