(A-C) The ZC3H11A, PI3K and AKT gene levels (n=3) were evaluated. (D, E) The IκBα and NF-κB gene levels (n=3). (F) Protein expression levels of ZC3H11A, PI3K, AKT, p-AKT and GAPDH were detected by ...

Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, ...

Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

(D, E) Confirmation and characterization of ADSCs-EVs by nanoparticle tracking analysis, transmission electron micr (A–C) The NF-κB pathway was up-regulated in ADSCs-EVs-treated OC cells ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences and School of Basic Medicine, ...

International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, 182 min-Zu Road, Wuhan 430074 ...

Both diseases are associated with various biological processes or molecular pathways, including mitochondrial dysfunction, reactive oxygen species production, the NF-kB pathway, HIF, IL-6, and IL-8.

ATP6V0A1 was identified as a key player in nephropathic cystinosis-related renal pathology, with antioxidants like ATX emerging as potential treatments to restore V0A1 expression, mitochondrial ...

Initial activation of naive mouse T cells resulted in NF-κB-dependent transient Prmt5 transcription and NF-κB, mTOR and MYC-dependent PRMT5 protein induction. In murine memory Th cells, transcription ...