Candida spp. is associated with almost 80% of all nosocomial fungal infections and is considered the major cause of blood stream infections and its infections involve a broad spectrum of superficial ...

New research might make an ‘undruggable’ target druggable – leading to new cancer drugs ...

The target, eukaryotic initiation factor 4E (eIF4E), is essential for the production of proteins linked to cell growth in a several tumour types – including breast and prostate cancer. Blocking this ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Clustered regularly interspaced short ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

The old adage says “a picture is worth a thousand words.” If that is the case, then a picture should receive the same amount of care and attention as those thousand words. Yet, scientific figures are ...

The eukaryotic translation initiation factor eIF4E can specifically bind to the cap structure of an mRNA 5' end, mainly regulating translation initiation and preferentially enhancing the translation ...

To explore the underlying mechanism, we first detected the phosphorylation of ERK1/2 and eIF4E in the hippocampus and found that it was lower in Tfm male mice than in WT male mice, it upregulated with ...

RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in ...

Our results reveal and characterize an unexpected interdependence between the two RNA helicases and eIF4G, and suggest that Ded1p is an integral part of eIF4F, the complex comprising eIF4G, eIF4A, and ...