C&EN15d
Synergistic Antitumor Immunotherapy via Mitochondria Regulation in Macrophages and Tumor Cells by an Iridium Photosensitizer
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...
eLife1y
PIMT is a novel and potent suppressor of endothelial activation
Furthermore, we found that PIMT inhibited LPS-induced toll-like receptor signaling through its interaction with TNF receptor-associated factor 6 (TRAF6) and its ability to methylate asparagine ...
Frontiers3y
Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity
LPS binds to TLR4, activates the MyD88-IRAK-TRAF6 pathway, and induces IKKβ activity within the IKK2 complex. Likewise, by binding IL-1R, IL-1α and IL-1β promote IKKβ activity through the ...
Frontiers6y
Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway
LPS, lipopolysaccharides; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB); Myeloid differentiation primary response 88 (MYD88), IRAK1, interleukin-1 receptor (IL-1R) associated ...
Nature10y
Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice
In this context, we recently demonstrated that the interaction between the costimulatory protein CD40 and its downstream adaptor protein tumor necrosis factor receptor-associated factor 6 (TRAF6 ...
eLife11y
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
Here we show that MAVS polymers recruit several TRAF proteins, including TRAF2, TRAF5, and TRAF6, through distinct TRAF-binding motifs. Mutations of these motifs that disrupted MAVS binding to TRAFs ...