In this context, we recently demonstrated that the interaction between the costimulatory protein CD40 and its downstream adaptor protein tumor necrosis factor receptor-associated factor 6 (TRAF6 ...

1Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. 2Department of Surgery, David Geffen School of ...

1Department of Experimental Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan. 2Department of Otolaryngology, Head and Neck Surgery, Institute of Medicine, University of Tsukuba, ...

Furthermore, we found that PIMT inhibited LPS-induced toll-like receptor signaling through its interaction with TNF receptor-associated factor 6 (TRAF6) and its ability to methylate asparagine ...

Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved ...

Here we show that MAVS polymers recruit several TRAF proteins, including TRAF2, TRAF5, and TRAF6, through distinct TRAF-binding motifs. Mutations of these motifs that disrupted MAVS binding to TRAFs ...

Upon receptor engagement, most TLRs recruit MyD88, which causes phosphorylation of IRAK4 and IRAK1. Subsequent interaction of the IRAKs with TRAF6 and NEMO leads to ubiquitination of the latter ...