PNAS28d
Ectopic mouse TMC1 and TMC2 alone form mechanosensitive channels that are potently modulated by TMIE
Recently, TMC1 and TMC2 (TMC1/2) have emerged as the pore-forming subunit of the MT channel. However, the functional study of TMC1/2 in heterologous cells has been challenging due to their lack of ...
PNAS28d
The RNA-binding protein RBPMS inhibits smooth muscle cell–driven vascular remodeling in atherosclerosis and vascular injury
An improved understanding of the mechanisms driving vascular smooth muscle cell (VSMC) modulation in the diseased vessel wall is needed to improve our approach to atherosclerotic plaque cap ...
Frontiers4y
Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear
In contrast to what has been observed, we find that tall hair cells that lack Tmc1 generally have substantial reductions in mechanosensitivity. In short hair cells that lack Tmc2 isoforms, ...