A team of scientists from China has made a breakthrough in understanding how aging affects muscles and found a possible way ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

A collaborative study led by Prof. Liu Guanghui from the Institute of Zoology of the Chinese Academy of Sciences and Dr. Wang ...

A collaborative study led by Prof. LIU Guanghui from the Institute of Zoology of the Chinese Academy of Sciences and Dr. WANG Si from Xuanwu Hospital ...

National Institute of Biological Sciences has disclosed pyrazole urea derivatives acting as inhibitor of nuclear factor κB kinase subunit ε (IKBKE; IKK-i) and/or TANK-binding kinase 1 (TBK1; NAK; T2K) ...

He died ~16 months after the onset of symptoms. Genetic testing identified a heterozygous two base pair deletion in the TBK1 gene (NM_013254.3:c.2099_2100del; p.(Val700Glyfs*2); online supplementary ...

2019). The investigation of the molecular mechanisms involved in the age-related enhanced microglial reactivity has recently identified the TANK1-binding kinase 1 (Tbk1) a player in the inflammaging ...

Some studies have suggested that this DNA can be recognized by cytosolic cGAS and recruit stimulator of interferon (IFN) genes (STING) at plasma membrane, which in turn activate, and is phosphorylated ...

Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases ...

binding cytoplasmic DNA and triggering the transcription of type I interferon (IFN), cytokine and chemokine genes in a manner dependent on IFN regulatory factor 3 (IRF-3), TANK-binding kinase 1 (TBK1) ...