Medscape14d
STAT5 Activity in Pancreatic B-cells
Known STAT5-target genes in β-cells are involved in the control of cell cycle progression, insulin production and insulin exocytosis, but it is likely that most STAT5-target genes in β-cells are ...
technologynetworks19d
Regulatory Immune Cells Regenerate the Thymus Following Cancer Therapy
“Our discovery — the regulatory T cell recirculation back to the thymus — promotes repair through a process that hasn't been described before and represents a novel pathway to regeneration in the ...
Frontiers19d
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons
ImmTAC is specific to both MHC-peptides (pHLA) located on the surface of the tumor and CD3s located on T cells. The ImmTAC is able to directly activate CD3 and its corresponding pathways in activated ...
Frontiers19d
Pathogenesis and novel therapeutics of regulatory T cell subsets and interleukin-2 therapy in systemic lupus erythematosus
Natural arising CD4+ regulatory T cells (Tregs) play a critical role in maintaining peripheral tolerance by suppressing inflammation and preventing autoimmune responses in SLE. Additionally, CD8+ ...
Le Lézard21d
City of Hope Scientists Identify Mechanism for Self-Repair of the Thymus, a Crucial Component of the Immune System
the regulatory T cell recirculation back to the thymus ? promotes repair through a process that hasn't been described before and represents a novel pathway to regeneration in the gland," said lead ...
EurekAlert!21d
City of Hope scientists identify mechanism for self-repair of the thymus, a crucial component of the immune system
LOS ANGELES — A team of international researchers led by scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, with ...