Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved ...

Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...

This dual action—targeting both protein aggregation and mitochondrial dysfunction—positions TFE3 as a promising therapeutic candidate for Parkinson's disease. By bolstering the brain's natural ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. TFE3 overexpression rescues autophagy defects of dopaminergic neurons in the AAV-α-Syn model. TFE3 ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative ...

However, it is not known whether TFEB plays a role in cholesterol clearance in NPC disease. Here, we show that transgenic overexpression of TFEB, but not TFE3 (another member of MiTF family) ...

The patient was diagnosed with metastatic TFE3-rearranged (MiT translocation) renal cell carcinoma and subsequently started on pembrolizumab and Lenvatinib followed by debulking surgery.

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China Department of Molecular, ...

Background: Xp11.2 translocation/TFE3 gene fusion associated with renal cell carcinoma (Xp11.2 RCC) exhibits unique biological characteristics and is associated with an increased incidence of tumor ...