WPRI 1223d
Hoth Therapeutics Announces Positive Findings on GDNF's Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved ...
The EMBO Journal24d
PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polo-like kinase 1 (PLK1) is a conserved ...
eLife3y
The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell
We investigated whether other members of the MEDLE gene family are similarly exported and selected MEDLE1 (cgd5_4580) and MEDLE6 (cgd6_5490) for epitope tagging. In IFAs, both tagged MEDLE1 and MEDLE6 ...
eLife8y
PDZD7-MYO7A complex identified in enriched stereocilia membranes
While more than 70 genes have been linked to deafness, most of which are expressed in mechanosensory hair cells of the inner ear, a challenge has been to link these genes into molecular pathways. One ...