WPRI 1223d
Hoth Therapeutics Announces Positive Findings on GDNF's Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved ...
BioSpace23d
Hoth Therapeutics Announces Positive Findings on GDNF’s Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...
eLife1mon
Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
This is an important study providing compelling evidence that the Mediator kinase module mediates an elevated inflammatory response, manifested by heightened cytokine levels, associated with Downs ...
Frontiers1mon
The role of ubiquitination and deubiquitination in cancer lipid metabolism
FBXW7β is a cytoplasmic subtype of FBXW7 that is frequently mutated in CRC and serves as an E3 ligase for FASN. Wei et al. found that CSN6 binds to both FBXW7β and FASN, and antagonizes the activity ...