Among other functions, the NK cells (natural killers, a type of lymphocyte forming part of the immune system) have the capacity to detect and eliminate cancer cells. But in some cases they cannot ...

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu Fabra University has developed a new tool that allows modifying these NK cells ...

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...

The authors show that knocking out SMAD4, human NK cells resist TGFβ and activin A suppression and demonstrate that SMAD4 knockout enhances the antitumor function of several NK cell products in ...

Case Presentation: Here, we report a case of stage IV pancreatic cancer in a patient with TSC2 and SMAD4 mutations treated with immunotherapy when the disease progressed after multi-line chemotherapy.

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, ...