Endochondral ossification is hard to recapitulate with human cells. Here, the authors generated SOX9+ sclerotomal progenitors from hPSCs, modeling key developmental stages of bone development and ...

Polycystic kidney disease (PKD), a family of genetic disorders that causes clusters of cysts to form on the kidney, is among the most common genetic disorders, affecting some 500,000 people in the ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common congenital condition that affects male children. The research highlights how ...

EMBL Barcelona researchers developed a new computational method to reconstruct embryonic development Laura Aviñó-Esteban from ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common congenital condition that affects male children.

Dr. Xing Liu, the lead researcher, stressed the significance of the findings: "This is the first study to pinpoint SOX9 as a key player in hypospadias development. By understanding how SOX9 ...

uclouvain.be. Objective The transcription factor SOX9 was recently shown to stimulate ductal gene expression in pancreatic acinar-to-ductal metaplasia and to accelerate development of premalignant ...

Their retinal pigment epithelium also produced less VEGF and had lower levels of a protein called Sox9, which is known to make the gene for VEGF more active. Goto et al. went on to show that simply ...

To do so, we analyzed a previous dataset that used ChIP-seq to profile Sox9 binding in mouse rib chondrocytes (Ohba et al., 2015). We found extensive overlap between Sox9-occupied sites and our open ...