This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

This part of the review will only focus on the role of mTOR/S6K1/S6, MARK and JNK signaling pathways in bone ... AKG has been shown to promote protein synthesis through the mTORC1-dependent pathway, ...

Mechanistically, NaAc activates GPR41 and GPR43 receptors, leading to the activation of the mTORC1 signaling pathway to promote the ... SREBP1 and the phosphorylation levels of mTOR, S6K1, and 4EBP1.

In agreement with previous reports, depriving immortalized mouse embryonic fibroblasts (MEFs) of all amino acids resulted in an initial loss of mTORC1 activity, as measured by the phosphorylation of ...