Patients with acute promyelocytic leukemia (APL) often present with potentially life-threatening hemorrhagic diathesis. The underlying pathomechanisms of APL-associated coagulopathy are complex.

Researchers have discovered that the protein JMJD1C plays a pivotal role in leukemia cell survival. Specifically, JMJD1C is recruited by RUNX1 to genomic loci, where it forms liquid-like condensates.

By interacting with RUNX1, a critical transcription factor, JMJD1C drives leukemia cell survival, making it a compelling therapeutic target. This discovery sheds light on how molecular mechanisms ...

Treatment stratification in ALL includes diverse (cyto)genetic aberrations, requiring diverse tests to yield conclusive data. We optimized the diagnostic workflow to detect all relevant aberrations ...

Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the ...

Background: Cell metabolic reprogramming is a hallmark of tumor prognosis, and fatty acid metabolism (FAM) plays a crucial role in the tumor microenvironment (TME). However, the relationship between ...